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rate and blocking probability targets. Admission control for both stream and elastic ows would take account of the measured stream load and the current count of the number of active elastic ows. Simple head of line priority is suf cient to meet the delay requirements of stream traf c while per ow queueing is the perferred solution for elastic traf c. Fair queueing among elastic ows leads to fair bandwidth sharing. However, performance could be improved by implementing packet scheduling schemes giving priority to short documents. The performance of rate sharing schemes like fair queueing and SRPT does not appear to be adversely affected by the heavy-tailed nature of the document size distribution. For any given application, a user might choose to set up a stream or an elastic ow. The choice depends on quality of service and cost. We have argued that openloop control can meet the strict delay requirements of stream traf c while closedloop control provides higher throughput for the transfer of elastic documents. The issue of providing price incentives to in uence user choices is discussed in the next section (see also Odlyzko [24] and Roberts [27]). 16.5.2 The Impact of Charging

For largely historical reasons, most users of the Internet today are charged on a at rate basis They pay a xed monthly charge that is independent of the volume of traf c they produce, although the charge does depend on the capacity of their network access line The major advantage of at rate pricing is its simplicity, leading to lower network operating costs A weakness is its inherent unfairness, a light user having to pay as much as a heavy user A more immediate problem is the absence of restraint inherent in this charging scheme, which may be said to contribute to the present state of congestion of the Internet Network usage can be controlled by the introduction of usage sensitive charging with rates determined by the level of congestion This is the principle of congestion pricing.

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Subsequent exposure may then give rise to an allergic reaction Skin sensitization tests generally follow protocols that are modi cations of the Buchler (dermal inductions) method or the Magnesson and Kligman (intradermal inductions) method The test animal commonly used in skin sensitization tests is the guinea pig; animals are treated with the test compound in a suitable vehicle, with the vehicle alone, or with a positive control such as 2,4-dinitrochlorobenzene (a relatively strong sensitizer) or cinnamaldehyde (a relatively weak sensitizer) in the same vehicle During the induction phase the animals are treated for each of 3 days evenly spaced during a 2-week period This is followed.

FIGURE 112 Prenylation inhibitors block hepatitis D virus (HDV) particle formation (a) The prenylation inhibitor FTI-277 inhibits production of HDV genome-containing particles Huh7 cells were cotransfected with HDV and hepatitis B virus (HBV) genome-encoding constructs, which results in the formation of infectious HDV particles41 The cells were maintained in a daily changed medium containing carrier alone (02% DMSO and 400 mM DTT) (lanes 2 and 8) or carrier plus FTI-277 at the following concentrations: 05 mM (lanes 3 and 9), 1 mM (lanes 4 and 10), 5 mM (lanes 5 and 11), 10 mM (lanes 6 and 12), or 20 mM (lanes 7 and 13) On day 10 after transfection, cells (lanes 1 to 7) and supernatants (lanes 8 to 13) were processed for northern analysis of HDV RNA Lane 1 corresponds to total RNA extracted from nontransfected cells subjected to carrier-containing medium (left panel).

Congestion pricing ideally leads to an economic optimum, where available resources are used to produce maximum utility While theoretically optimal schemes like the ``smart market'' [23] are unlikely to be implemented for reasons of practicality, it has been argued that the congestion control objective can be acheived simply by offering a number of differentially priced service classes with charges increasing with the expected level of quality of service [28] Users determine the amount they are charged by their choice of service class They have an incentive to choose more expensive classes in times of congestion.

by a 2-week rest period followed by the challenge phase of the test This consists of a 24-hour topical treatment carried out as described for primary skin irritation tests The lesions are scored on the basis of severity and the number of animals responding (incidence) If there is a greater skin reaction in the animals given induction doses compared to those given the test material for the rst time, the compound is considered to be a dermal sensitizer Other test methods include those in which the induction phase is conducted by intradermal injection together with Freund s adjuvant (a chemical mixture that enhances the antigenic response) and the challenge by dermal application, or tests in which both induction and challenge doses are topical but the former is accompanied by intradermal injections of Freund s adjuvant.

Such schemes suffer from a lack of transparency: How can users tell if the network provider isn't deliberately causing congestion Why should they pay more to an inef cient provider Are they currently paying more than they need to, given current traf c levels Note that congestion pricing is not generally employed in other service industries subject to demand overloads such as electricity supply, public transportation, or the telephone network An alternative is to charge for use depending on the amount of resources used per transaction, accounting possibly for distance (number of hops) as well as volume..

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